Turk J Med Sci. 2016 Jan 5;46(1):194-202. doi: 10.3906/sag-1411-35.
Apitherapy products enhance the recovery of CCL4-induced hepatic damages in rats.
Saral Ö1, Yildiz O2, Aliyazicioğlu R3, Yuluğ E4, Canpolat S5, Öztürk F6, Kolayli S7.
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Abstract
BACKGROUND/AIM:
Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats.
MATERIALS AND METHODS:
Animals were fed with honeybee products for 7 days following CCl4 injection. Development of liver damage and oxidative stress were monitored by measuring the activities of the enzymes alanine transaminase, aspartate transaminase, malondialdehyde, superoxide dismutase, and catalase. Antioxidant capacities of the bee products were identified using FRAP and DPPH assays, as well as by measuring total phenolic and flavonoid contents.
RESULTS:
The antioxidant activities of the honeybee products were highest in propolis, followed, in order, by pollen, honey, and royal jelly. Despite their different levels of antioxidant capacity, their roles in the prevention of liver damage induced by CCl4 were very similar, which can be explained through their bioavailability to the treated animals.
CONCLUSIONS:
Our results suggest that honey, propolis, pollen, and royal jelly significantly enhanced the healing of CCl4-induced liver damage, partially due to their antioxidant properties and bioavailability.
PMID: 27511354 DOI: 10.3906/sag-1411-35
[PubMed – in process]
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.