Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis.
Basnet P, Matsushige K, Hase K, Kadota S, Namba T.
Research Institute for Wakan-Yaku (Traditional Sion-Japenese Medicines), Toyama Medicine and Pharmaceutical University, Japan.
Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4-di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.