Isolation and characterization of cytotoxic diterpenoid isomers from propolis.*

Z Naturforsch C. 1997 Sep-Oct;52(9-10):702-4.

Isolation and characterization of cytotoxic diterpenoid isomers from propolis.

Matsuno T1, Matsumoto Y, Saito M, Morikawa J.

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Abstract

The methanol extract of Brazilian propolis was fractionated by HPLC, based on HuH13 (human hepatocellular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H30O3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-17-oic acid).

PMID: 9374000

[Indexed for MEDLINE]

 

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.