Cell Immunol. 2016 Sep 29. pii: S0008-8749(16)30114-9. doi: 10.1016/j.cellimm.2016.09.014. [Epub ahead of print]
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis.
Dos Santos Thomazelli AP1, Tomiotto-Pellissier F2, da Silva SS1, Panis C3, Orsini TM1, Cataneo AH1, Miranda-Sapla MM1, Custódio LA4, Tatakihara VL4, Bordignon J5, Silveira GF5, Sforcin JM6, Pavanelli WR1, Conchon-Costa I1.
American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control.
Copyright © 2016 Elsevier Inc. All rights reserved.
PMID: 27702443 DOI: 10.1016/j.cellimm.2016.09.014
[PubMed – as supplied by publisher]
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.