Journal of Ocular Pharmacology and Therapeutics VOL. 30, NO. 9 |
Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases
Sumeyya Akyol, Veli Ugurcu, Mehmet Balci, Ayse Gurel, Gonul Erden, Ozlem Cakmak, and Omer Akyol
Published Online: 6 Nov 2014 https://doi.org/10.1089/jop.2014.0046
Abstract
As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.