Drug Des Devel Ther. 2015 Dec 21;9:6483-8. doi: 10.2147/DDDT.S97797. eCollection 2015.
Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture.
Kazancioglu HO1, Aksakalli S2, Ezirganli S1, Birlik M2, Esrefoglu M3, Acar AH1.
Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new applications have been investigated. The present study aimed to investigate the possible effectiveness of caffeic acid phenethyl ester (CAPE) on new bone formation in rat midpalatal suture after RME.
MATERIALS AND METHODS:
Twenty male Sprague Dawley rats were used in this study. The animals were randomly divided into two groups as control and CAPE group. In the CAPE group, CAPE was administered systemically via intraperitoneal injection. RME procedure was performed on all animals. For this purpose, the springs were placed on the maxillary incisors of rats and activated for 5 days. After then, the springs were removed and replaced with short lengths of rectangular retaining wire for consolidation period of 15 days. At the end of the study, histomorphometric analysis was carried out to assess new bone formation.
New bone formation was significantly greater in the CAPE group than the control group (P<0.05). CAPE enhances new bone formation in midpalatal suture after RME.
These results show that CAPE may decrease the time needed for retention.
PMID: 26730181 [PubMed – in process] PMCID: PMC4694669
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.