J Intercult Ethnopharmacol. 2016 Aug 17;5(4):439-443.

Effects of a diet containing Brazilian propolis on lipopolysaccharide-induced increases in plasma plasminogen activator inhibitor-1 levels in mice.

Ohkura N1, Oishi K2, Kihara-Negishi F3, Atsumi GI1, Tatefuji T4.

Author information

Abstract

BACKGROUND:

Brazilian propolis has many biological activities including the ability to help prevent thrombotic diseases, but this particular effect has not been proven. Plasma levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, increase under inflammatory conditions such as infection, obesity and atherosclerosis and such elevated levels predispose individuals to a risk of developing thrombotic diseases.

AIM:

This study aimed to determine the effects of a diet containing Brazilian propolis on lipopolysaccharide (LPS)-induced increases in plasma PAI-1 levels.

MATERIALS AND METHODS:

Mice were fed with a diet containing 0.5% (w/w) Brazilian propolis for 8 weeks. Thereafter, the mice were subcutaneously injected with saline containing 0.015 mg/kg of LPS and sacrificed 4 h later.

RESULTS:

Orally administered Brazilian propolis significantly suppressed the LPS-induced increase in PAI-1 antigen and its activity in mouse plasma.

CONCLUSION:

This study indicated that Brazilian propolis contains natural products that can decrease thrombotic tendencies in mice.

PMID: 27757277 PMCID: PMC5061490 DOI: 10.5455/jice.20160814112735

[PubMed – in process] Free PMC Article

 

pubmed logo

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.