Chemical markers and antifungal activity of red propolis from Sergipe, Brazil
Lucyana Santos de MENDDNÇA1, Flávia Manuella Ribeiro de MENDDNÇA1,
Yzila Liziane Farias Maia de ARAÚJD2, Edilson Divino de ARAÚJD2, Suyare Araújo RAMALHD2, Narendra NARAIN2, Sona JAIN2*, Sara Cuadros DRELLANA3,
Francine Ferreira PADILHA1,4, Juliana Cordeiro CARDDSD1,4
Abstract
The aim of this study was to analyze the physicochemical properties and antifungal activities of the red propolis samples from Sergipe, Brazil, and also evaluate their variability throughout the year. The characterization of the hydroalcoholic extract (HPE) of the red propolis samples was performed monthly from October 2009 to September 2010. The concentrations of the bioactive compounds varied during the year, but their chromatographic profiles were similar. Four compounds were identified by comparison with authentic standards. Formononetin was one of the predominant compounds in all propolis extracts. In our study, it was observed that all the propolis samples inhibited the growth of Candida species. Multivariate analysis confirmed the variations in chemical composition and color of the HPEs throughout the year. The biological activities of the HPEs were statistically significant (p<0.05), and all samples exhibited antifungal properties.
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.