Molecules. 2017 Jul 11;22(7). pii: E1159. doi: 10.3390/molecules22071159.
Characterization and Biological Evaluation of Propolis from Poland.
Popova M1,2, Giannopoulou E3, Skalicka-Woźniak K4, Graikou K5, Widelski J6, Bankova V7, Kalofonos H8, Sivolapenko G9, Gaweł-Bęben K10, Antosiewicz B11, Chinou I12.
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Abstract
In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populusnigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populustremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95-1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25-1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health.
PMID: 28696397 DOI: 10.3390/molecules22071159
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.