Exp Eye Res. 2015 May;134:53-62. doi: 10.1016/j.exer.2015.03.014. Epub 2015 Mar 17.
Choi JH1, Roh KH1, Oh H2, Park SJ1, Ha SM1, Kang MS3, Lee JH4, Jung SY5, Song H1, Yang JW6, Park S7.
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Abstract
Experimental autoimmune uveoretinitis (EAU) is an autoimmune disease that models human uveitis. Caffeic acid phenethyl ester (CAPE), a phenolic compound isolated from propolis, possesses anti-inflammatory and immunomodulatory properties. CAPE demonstrates therapeutic potential in several animal disease models through its ability to inhibit NF-κB activity. To evaluate these therapeutic effects in EAU, we administered CAPE in a model of EAU that develops after immunization with interphotoreceptor retinal-binding protein (IRBP) in B10.RIII and C57BL/6 mice. Importantly, we found that CAPE lessened the severity of EAU symptoms in both mouse strains. Notably, treated mice exhibited a decrease in the ocular infiltration of immune cell populations into the retina; reduced TNF-α, IL-6, and IFN-γ serum levels: and inhibited TNF-α mRNA expression in retinal tissues. Although CAPE failed to inhibit IRBP-specific T cell proliferation, it was sufficient to suppress cytokine, chemokine, and IRBP-specific antibody production. In addition, retinal tissues isolated from CAPE-treated EAU mice revealed a decrease in NF-κB p65 and phospho-IκBα. The data identify CAPE as a potential therapeutic agent for autoimmune uveitis that acts by inhibiting cellular infiltration into the retina, reducing the levels of pro-inflammatory cytokines, chemokine, and IRBP-specific antibody and blocking NF-κB pathway activation.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Comment on ‘Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model’ by Choi J.H. et al. [Exp. Eye Res. 134 (2015) 53-62]. [Exp Eye Res. 2015]
PMID: 25795054 DOI: 10.1016/j.exer.2015.03.014
[PubMed – indexed for MEDLINE]
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.