Future Med Chem. 2016 Oct 14. [Epub ahead of print]
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Coleman JJ1,2,3, Komura T1, Munro J2, Wu MP2, Busanelli RR4, Koehler AN4,5, Thomas M4, Wagner FF4, Holson EB4,6, Mylonakis E1,2.
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Abstract
AIM:
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.
RESULTS:
CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens.
CONCLUSION:
Caenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds.
PMID: 27739327 DOI: 10.4155/fmc-2016-0085
[PubMed – as supplied by publisher]
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.